Uncovering the potential of Proteins & Post-Translational Modifications to promote Personalized Medicine
Proteins, found in every cell throughout the body, are essential for carrying out all biological processes. Protein activity reflects the net effect of both biological and environmental factors and thus ultimately determine the physiological state and the ability to fight and overcome disease.
Protein function is controlled by a set of chemical modifications that occur after a protein is produced, termed Post-Translational Modifications (PTMs). PTMs such as ubiquitination, sumoylation, neddylation, phosphorylation and others are found in all proteins in the cell and regulate whether a protein will be active or not, where it will reside in the cell, and when it will be sent for disposal. Therefore, PTMs dictate numerous key molecular mechanisms, which determine the physiological state and the ability to fight and overcome disease, and are implicated in various diseases such as Cancer, Infectious and Autoimmune diseases.
Despite the importance of the ubiquitin family and other post-translational modifications, the ability to analyze clinical samples, at the level of post-translational modifications with current available technologies is very limited and only a few high throughput analytical tools are available.